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Blood biomarkers of telltale signs of early Alzheimer’s disease in the brain of his patient, 55-year-old entrepreneur Simon Nicholls, had all but disappeared in a mere 14 months. “I don’t use the term ‘reverse.’ I don’t know what reverse means when it comes to the field of Alzheimer’s,” Isaacson said. ‘It was time to turn to my brain’Slowly, Nicholls’ heart condition began to improve, but the bad news didn’t end there. A brain scan found telltale signs of vascular damage in Nicholls’ brain, which occurs when the tiniest blood vessels are starved of oxygen. Not only was Nicholls blood negative for amyloid and tau, the test suggested that his brain amyloid might be normal, with no distinguishable signs of the disease.
Persons: Sanjay Gupta, Anderson Cooper ”, Richard Isaacson, Simon Nicholls, , , Isaacson, “ Simon, ” Isaacson, Nicholls, ” Nicholls, Anderson Cooper, It’s, APOE4, Simon, ” Simon Nicholls, Sylver, Lewy, Richard Isaacson ‘, APOE ε4, “ I’ve, Isaacson doesn’t, “ I’m, Shocked, Dr, we’d, “ It’s, Salvadore, Richard Isaacson “, ‘ It’s, I’m Organizations: CNN, telltale, ” CNN, Boca Raton Locations: Boca Raton , Florida, New York City, Florida, Nature, Miami, Isaacson’s Florida, tirzepatide
If you'd told me 10 years ago I'd feel ashamed of losing weight, I wouldn't have believed you. I've been on a roller coaster of body shame and acceptance since I was 12, which, at times, led to bouts of disordered eating. My primary doctor suggested I try a medical weight loss program, which involves seeing a nutritionist and weight loss doctor monthly, as well as prescription weight loss drugs. I've been scared because of the hurtful commentary and speculation I see online about others losing weight by taking medication. However, I am conscience-stricken for taking weight loss medicine when all I am trying to do is improve my health.
Persons: you'd, I've, I'd, I'm
Saudi Arabia's sprawling megacity, Neom, is billed as a chance to live in the "new future." AdvertisementOfficials say Neom will be a "cognitive city." The chosen candidate will control and operate the fish laboratory, ensuring high standards of fish welfare and supporting surveillance and investigation activities into fish health and disease control. Developers have said they want the island resort Sindalah to act as an "exclusive gateway to the stunning Red Sea." An image showing a nighttime view of mountains in the region in northwest Saudi Arabia where planners say Neom will be built.
Persons: , Neom, Prince Mohammed bin Salman's, Neom's Organizations: Service, Tech, NEOM Community School Locations: Saudi, Saudi Arabia, Tabuk, Sindalah, Gulf, Aqaba, Neom, Oxagon
CNN —Flowers and brunch are lovely for Mother’s Day, but there’s an invaluable gift almost every mom would enjoy: a healthier body image. But almost all postpartum moms, celebrity or not, face an unspoken mandate to “bounce back” to their pre-baby body. If moms feel preoccupied with their appearance, exercise or what they eat (even “healthy eating”), it could be a sign of significant maternal mental health problems. “The body isn’t what it was before. Awareness of these external diet culture directives can help moms start to push back against unrealistic and harmful ideals.
Persons: Oona Hanson, CNN —, I’ll, Gisele Bündchen, shouldn’t, you’ve, , Jen McLellan, Jill Schwartz, ” Schwartz, Debra Benfield, perimenopause, ” Benfield, It’s, Benfield, ” McLellan, , Agne Jurkenaite, McLellan Organizations: CNN, Vogue, National Alliance for Locations: Albuquerque , New Mexico, Los Angeles, Winston, Salem , North Carolina, midlife
Like other coral reefs, over the last few decades, this vibrant ecosystem has been suffering from the effects of climate change, with the National Oceanic and Atmospheric Administration recently reporting a fourth global mass bleaching event – the second in the last decade. Bleaching happens when the corals become stressed due to changes in their environment and expel the colorful algae living on them. University of MiamiIn partnership with the city of Miami Beach, two hybrid reefs were deployed in March 2023. Coral gardeningLirman’s team has been growing and testing coral colonies at the university for more than 15 years. A global problemOcean ecosystems are declining and suffering around the world, Lirman says.
Persons: , Diego Lirman, Lirman, ” Lirman, , Emily Esplandiu, they’ve, “ We’re Organizations: CNN, Miami, National Oceanic, Atmospheric Administration, University of Miami, North Miami Beach, International Maritime Organization, Miami Beach, Dade, US Department of Defense Locations: Miami Beach , Florida, North Miami, Miami Beach, Miami
The results of pure-breeding, on display starting this Saturday at the Westminster Kennel Club Dog Show in New York, are profound. Erich Andres/United Archives, via Getty Images Modern shepherds have more pronounced slopes A German shepherd at the 2013 Westminster Kennel Club Dog Show. Imagno/Getty Images Modern pugs have smushed, round faces A pug at the 2013 Westminster Kennel Club Dog Show. Fox Photos/Getty Images Modern chows are slightly larger, with more fluffy fur A chow at the 2013 Westminster Kennel Club Dog Show. Fox Photos/Getty Images Modern bull terriers have more football-shaped heads A bull terrier at the 2013 Westminster Kennel Club Dog Show.
Persons: Davis, Erich Andres, Fred R, Conrad, Danika Bannasch, Cane Corso, Pugs, Imagno, Chow chows, chow, Bull Organizations: American Kennel Club, University of California, Wisdom Health, Westminster Kennel, Danes, United, Getty, The New York Times, Fox, American Kennel Locations: Finland, New York, Rhodesian
Cancer rates in people under 45 have surged over the past two decades, researchers found. AdvertisementNew evidence shows how sharply colon cancer rates are skyrocketing in people younger than 45. A team of researchers led by Dr. Islam Mohamed, a physician at the University of Missouri-Kansas City, analyzed CDC data on colon cancer incidence in Americans aged 10 to 44 over two decades. They found that cases have more than tripled in teenagers and more than doubled for people in their early 20s. This story is available exclusively to Business Insider subscribers.
Persons: , Dr, Islam Mohamed Organizations: Service, University of Missouri, Kansas City, Business Locations: Kansas
Wynn Resorts — The resort-and-casino stock added 2.3% on the back of better-than-expected first quarter earnings. However, the California-based company saw $253 million in revenue for the three-month period, above the consensus forecast of $247 million. Toast — The cloud-based restaurant management software company saw shares jump more than 2% in extended trading after its earnings report. Twilio expects revenue to range between $1.05 billion and $1.06 billion versus an LSEG average estimate of $1.08 billion. The quarter "saw early indications of market share gains in hereditary cancer and prenatal testing," management said.
Persons: Reddit, Lyft, Rivian, Wynn, LSEG, Sonos, , Yun Li, Hakyung Kim, Pia Singh, Darla Mercado, Scott Schnipper, Samantha Subin Organizations: FactSet, LSEG, Rivian, Wynn Resorts, Arts, Arista Networks, Wall, Myriad Locations: California
Scientists are proposing a new way of understanding the genetics of Alzheimer’s that would mean that up to a fifth of patients would be considered to have a genetically caused form of the disease. Currently, the vast majority of Alzheimer’s cases do not have a clearly identified cause. The new designation, proposed in a study published Monday, could broaden the scope of efforts to develop treatments, including gene therapy, and affect the design of clinical trials. It could also mean that hundreds of thousands of people in the United States alone could, if they chose, receive a diagnosis of Alzheimer’s before developing any symptoms of cognitive decline, although there currently are no treatments for people at that stage. The new classification would make this type of Alzheimer’s one of the most common genetic disorders in the world, medical experts said.
Locations: United States
That entrepreneurial, technology-focused spirit has driven Underwood to an illustrious career at some of the industry's biggest companies, including Google, X, Slack, and Intel. As she built products at these tech giants, Underwood quietly invested in over 50 startups, including the genetics-testing unicorn Color and the cap-table giant Carta. Underwood began investing while at X, then called Twitter, where she was the company's director of product. Shortly after, #Angels was born, the investment collective cofounded by Underwood, Verrilli, Jana Messerschmidt, Chloe Sladden, Katie Stanton, and Vijaya Gadde. Since 2015, the group has backed over 100 startups, including Forward, Clubhouse, Instacart, Material Security, and Airtable.
Persons: Underwood, she'd, Slack, Jessica Verrilli, who'd, Stewart Butterfield, Cal Henderson, Ev Williams, Jack Dorsey, Verrilli, Jana Messerschmidt, Chloe Sladden, Katie Stanton, Vijaya Gadde, you've, I've, they've Organizations: Amarillo College, Business, Google, Intel, GV, Cue, Twitter, Health, Security, Slack Locations: Amarillo , Texas, Amarillo, Termina, San Francisco
Plenty of retailers have kicked off Mother's Day sales to make it easier to get a thoughtful present without breaking the bank. No matter what type of mom you have, we've gathered the best Mother's Day deals on flower delivery, jewelry, smart photo frames, and more. 5 best Mother's Day sales 1-800-Flowers: Get up to 40% off Mother's Day arrangements. More Mother's Day salesFrequently asked questionsWhen is Mother's Day? The best Mother's Day sales typically kick off well before the actual holiday since they're intended to help shoppers score discounts on gifts in time for the day of.
Persons: we've, Mason, Farmgirl, they're Organizations: Business, Mother's, Apple, Amazon, Metro Locations: Oslo
Olive oil may lower risk of dementia-related death
  + stars: | 2024-05-06 | by ( Kristen Rogers | ) edition.cnn.com   time to read: +5 min
CNN —A daily spoonful of olive oil could lower your risk of dying from dementia, according to a new study by Harvard scientists. Olive oil can be a healthy, tasty addition to foods such as sandwiches and salads. Replacing 5 grams — around 1.2 teaspoons — of margarine or mayonnaise consumed daily with olive oil was associated with an 8% to 14% lower risk of death from dementia. “It is also possible that olive oil has an indirect effect on brain health by benefiting cardiovascular health,” she added. Besides cooking with olive oil, you can also use it to make salad dressings or vinaigrettes, mayonnaise, pesto or bread dip.
Persons: Anne, Julie Tessier, Harvard University’s T.H, , Duane Mellor, ” Mellor, Tessier, , David Curtis, Mellor, Curtis, Olive, it’s Organizations: CNN, Harvard, JAMA, American Society, Harvard University’s, of Public Health, Nurses, Health, Aston Medical School, Aston University, University College London Locations: Chan, North America, United Kingdom
For even more discounts, check out our roundup of the best Best Buy deals and the best Mother's Day sales. Amazon sale quicklinks Amazon Echo : Get up to 50% off select Echo speakers. Amazon Fire : Get up to 40% off select Fire TV streaming devices. : Get up to 40% off select Fire TV streaming devices. Shop at AmazonThis is just a small sample of this weekend's top Amazon sale picks.
Persons: I've, Ralph Lauren, De'Longhi, Siri, It's Organizations: Business, Walmart, Apple, Echo, Sporting, Amazon Apple, Apple Health, Amazon Bose, Google, Amazon Fire
Scientists identify ‘degrees of Kevin Bacon’ gene
  + stars: | 2024-05-02 | by ( Katie Hunt | ) edition.cnn.com   time to read: +6 min
Even humble fruit flies organize themselves into regularly spaced clusters, researchers have found. Within those social networks, certain individuals will often stand out as “gatekeepers,” playing an important role for cohesion and communication within that group. New research published Tuesday in the journal Nature Communications has identified a gene responsible for regulating the structure of social networks in fruit flies. The study opened up new opportunities for exploring the molecular evolution of social networks and collective behavior in other animals. FLPA/ShutterstockThe gene behind fruit fly social networksThe researchers investigated a number of gene candidates in fruit flies, a common lab organism used in the study of genetics.
Persons: , Kevin Bacon, Bacon, Joel Levine, Rebecca Rooke, ” Levine, Levine, , ” Allen J, Moore, wasn’t, ” Moore Organizations: CNN, Nature Communications, University of Toronto, University of Georgia’s Locations: Philadelphia, University of Toronto Mississauga
A study found linked between healthy lifestyle habits and living longer. AdvertisementHealthy lifestyle choices could help us live up to five years longer, regardless of our genetic makeup, a study suggests. At the same time, a healthy lifestyle appeared to offset the effects of genes linked to a shorter lifespan by 62%. Making favorable lifestyle choices despite having genes linked to a shorter lifespan was linked to living 5.22 years longer than those who made unfavorable choices. However, she said that the effects of lifestyle factors in the study were notable because they suggest that while we can't change our genes, healthy habits may lessen their impact.
Persons: , Liz Williams, wasn't, Williams, It's Organizations: Service, University of Sheffield, Centers for Disease Control
Now, a new study has quantified the risk of depression during the transition, known as perimenopause — showing that women in this stage are about 40% more likely to experience the mental health condition than premenopausal women. The authors conducted the study — which is a review of seven studies totaling 9,141 women — to provide an estimate for the risk of developing clinical, diagnosed depression or depressive symptoms at different menopausal stages. The authors didn’t find a significant difference in risk of depression for postmenopausal women compared with premenopausal women. Badawy is now an associate graduate mental health worker at the Barnet, Enfield and Haringey Mental Health NHS Trust in London. And doctors should develop and maintain relationships with mental health providers to whom they can refer patients diagnosed with depression.
Persons: , Aimee Spector, ” Spector, , didn’t, Stephanie Faubion, Penny, Bill George, Faubion wasn’t, Yasmeen Badawy, ” Faubion, Faubion, Rebecca Thurston, wasn’t, Thurston, Organizations: CNN, Disorders, University College London, Johns Hopkins Medicine, Mayo Clinic’s Center, Women’s Health, Barnet, Haringey Mental Health, Trust, Pittsburgh, University of Pittsburgh, Lifeline Locations: United States, Australia, China, Netherlands, Switzerland, Minnesota, Enfield, Haringey, London
CNN —Even if your genetics put you at greater risk for early death, a healthy lifestyle could help you significantly combat it, according to a new study. Individuals with genetic risk could extend their lifespan by up to 5.5 years with a healthy lifestyle, the data showed. “Adherence to a healthy lifestyle could substantially attenuate the lifespan reduction for individuals with genetic susceptibility to a shorter lifespan,” Li said. But researchers were able to identify four factors that were associated with the biggest impact on risk of early death. Making lifestyle changesBuilding a healthier lifestyle may sound like a major undertaking, but manageable steps can help you get there.
Persons: Xue Li, Dr, Aladdin Shadyab, Shadyab, Li, ” Li, , Rosamund Dean, , you’ve Organizations: CNN, School of Public Health, Zhejian Univeristy, of Medicine, University of California, National Institute for Data Science, Health, Medicine, Zhejiang University, US Centers for Disease Control, CDC, of Locations: China, University of California San Diego, of Columbia, Guam, Puerto Rico
With opulent graves but no written records, the empire and its people have remained largely in the shadows of history until recently. But a landmark April 2022 study involving ancient DNA taken from the graves of the Avar elite shed light on the empire’s far-flung origins. A tiny sample is drilled from a bone at the ancient DNA laboratory at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany. In the case of men, researchers found two partners in 10 cases, three partners in four cases and four partners in one case. “Polygamy (having multiple marriage partners), serial monogamous marriages and extramarital relations are all possible explanations,” she said.
Persons: , Zsófia Rácz, Rácz, aren’t, Guido Alberto Gnecchi, Max Planck, Eötvös Loránd University Múzeum Lara Cassidy, , polygyny, Ruscone, Cassidy, Bryan Miller, wasn’t Organizations: CNN, of Archaeological Sciences, Eötvös Loránd, Múzeum, University’s, Archaeological Sciences, Max, Max Planck Institute, Eötvös Loránd University, Trinity College Dublin, Turks, Central, University of Michigan Locations: Central, Eastern Europe, Hungary, Rákóczifalva, Budapest, Leipzig, Germany, Europe, Mongolia, Caucasus, what’s, Constantinople, Byzantine, Eurasia
When it comes to taking risks, Netflix co-founder Reed Hastings has an important rule of thumb. "I try to take a lot of risks on things that are recoverable," Hastings said in a recent conversation on entrepreneur Tim Ferriss' podcast. A two-way door risk is easy to take because it's reversible, so "you can come back in and pick another door," Bezos said. But a one-way door risk probably can't be undone. In 2017, Hastings told CNBC he was actually pushing his content team to "take more risk" in that regard.
Persons: Reed Hastings, Hastings, Tim Ferriss, Jeff Bezos, Lex, Bezos, — Hastings, Ferriss, Fortune Organizations: Netflix, Amazon, CNBC, Peace Corps Locations: Swaziland, Africa
The scientists conducted over 600 experiments on themselves, breathing CO2, oxygen, and more gases. download the app Email address Sign up By clicking “Sign Up”, you accept our Terms of Service and Privacy Policy . Hulton-Deutsch Collection/CORBIS/Corbis via Getty ImagesThe seizures were bad enough in a dry hyperbaric chamber, but one of the researchers nearly drowned breathing oxygen while submerged in water. AdvertisementOne of the British X-Craft submarines that required special calculations about how long it could be under the water without resurfacing for fresh air. Their dangerous experiments not only contributed to the D-Day invasion, but also contributed to the science behind modern-day scuba diving.
Persons: , Rachel Lance, Bettmann, John Burdon Sanderson Haldane, Haldane, Thetis, John Haldane, Hulton, Martin Case Organizations: British Admiralty, Service, Channel, British Army, intel, Royal Navy, British Royal Navy, Getty, University College London, Deutsch Locations: Normandy
CNN —Using acetaminophen, the active ingredient in Tylenol, during pregnancy was not associated with increased risk of autism, ADHD or intellectual disability in children, a new study found. “This is a very extensive and well-designed study that found no association between acetaminophen use and neurodevelopmental impairment, including autism and ADHD,” he said. For example, the study found that parents who have neurodevelopmental disorders — which have strong heritability — are also more likely to use pain medications, like acetaminophen, during pregnancy. This relationship might make it seem like children who are exposed to acetaminophen during pregnancy are more likely to develop neurodevelopmental disorders, when, in fact, their increased risk is due to genetics, according to the study. The study found significant differences between birthing parents with higher acetaminophen use and those with lower or no use.
Persons: , ” Dr, Eric Brenner, ” Brenner, , Brenner, Dr, Sanjay Gupta, judiciously, Yalda Afshar Organizations: CNN, Karolinska Institute, Drexel University, Duke University, Food and Drug Administration, European Medicines Agency, Get CNN, CNN Health, FDA, David Geffen School of Medicine, UCLA Locations: Sweden
When I went sober six years ago, dating and getting laid was the last thing on my mind. After all, I'd gone sober for a reason: to self-optimize, and I couldn't do that with a man snoring in my ear. It felt like alcohol and I had always been in an open relationship, but now it was time for me to fly solo. Don't obsess over small thingsThat said, I couldn't blame all my past failures on the men I'd dated. Talking to men sober felt like doing it for the first time.
Persons: I'd, I'd pined, , pesky, I'm, Evan Lambert, he's, Evan Lambert Be Organizations: Service Locations: New York City
Ramakrishnan shares his perspectives on the realities of aging, death and immortality. Nobel Prize-winning molecular biologist Venki Ramakrishnan offers his perspective on aging, death and immortality. But biologists don’t believe that aging and death are programmed in the sense that a fertilized egg is programmed to develop into a human being. Larger animals tend to live longer. CNN: What are the societal costs of the quest to cheat aging and death, particularly inequities?
Persons: Harper Collins, Nobel, Venki Ramakrishnan, Venki, they’ve, Jeanne Calment, Dolly, I’m, it’s, Don’t, Steven Johnson, we’re, we’d, It’s, Jessica DuLong, Organizations: CNN, Aging Locations: French, Brooklyn , New York
CNN —Researchers looking for clues about why some types of cancer are on the rise in younger adults say they’ve found an interesting lead: a connection to accelerated biological aging. What faster aging could tell us about cancer riskAfter adjusting the data for factors they thought might bias their results, the researchers found that accelerated aging was associated with increased risk for cancer. “There are medications that also look like they can slow down accelerated aging,” said Blaes, who is testing two of them in cancer survivors. Cancer survivors often show greater biological aging, perhaps because of the after effects of therapies like chemotherapy and radiation. It’s not quite prime time, where we would go out and prescribe those medications for people, but this is really, really important work,” Blaes said.
Persons: they’ve, It’s, , Yin Cao, Louis, Cao, Tian, ” Cao, Anne Blaes, , Blaes, Dr, Sanjay Gupta, ” Blaes Organizations: CNN, Washington University School of Medicine, American Association of Cancer, University of Minnesota, Hematology, Oncology, UM, CNN Health, Cancer Locations: St, San Diego
CNN —Ancient DNA recovered from the remains of a sixth century Chinese emperor who ruled during the country’s dark ages has shed some light on what the leader may have looked like. Emperor Wu ruled China as part of the Northern Zhou dynasty from 560 to 580 and is credited with unifying the northern part of ancient China during a particularly chaotic period. “Our analysis shows Emperor Wu had typical East or Northeast Asian facial characteristics.”The authors said they hoped ancient DNA might shed light on Wu’s cause of death. The genetic analysis showed that Emperor Wu intermarried with ethnically Han Chinese, China’s dominant ethnic group today. “It’s interesting to see the genetic study, but none of the findings of this genetic study are surprising at all,” Miller said.
Persons: Emperor Wu, Wu, , Shaoqing Wen, Tobias Houlton, University of Dundee , Houlton, Jeong Hoongwon, Jeong, ” Jeong, Franks, Bryan Miller, Miller, wasn’t, ” Miller, Organizations: CNN, Fudan University, University of Dundee, Seoul National University’s School of Biological Sciences, Han, Central, University of Michigan Locations: China, Mongolia, Shanghai, Seoul, North
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